INFLUENCE OF ESSENTIAL OILS ON MICROORGANISMS OF DIFFERENT TAXONOMIC POSITIONS ICOMPARISON WITH MODERN ANTIBIOTICS. Report I. EFFECT OF ROSE ESSENTIAL OIL AND ANTIBIOTIC SUBSTANCES ON SOME GRAM-NEGATIVE BACTERIA 

Markelova Natalia Nikolaevna, Applicant, sub-department of general and clinical pharmacology, Penza State University (40 Krasnaya street, Penza, Russia), nataljamarkelova@yandex.ru
Semenova Elena Fedorovna, Candidate of biological sciences, professor, sub-department of general and clinical pharmacology, senior staff scientist, Penza State University (40 Krasnaya street, Penza, Russia), sef1957@mail.ru
Shpichka Anastasia Iosifovna,  Candidate of biological sciences, associate professor, sub-department of general and clinical pharmacology, Penza State University (40 Krasnaya street, Penza, Russia), ana-shpichka@yandex.ru
Zhuchenko Elena Vladimirovna, Student, Penza State University (40 Krasnaya street, Penza, Russia), lenochek_zhuchenko@mail.ru 

579.222:(579.842+579.44):615.32:615.33 

Background. During recent years different medicinal plants and vegetable extracts are of interest due to their antibiotic activity. The researches carried out testify to the possibility of these oils to be used for treatment of human infections. The aimof the study is to investigate antibacterial effects of rose oil in comparison with antibiotics on some opportunistic Gram-negative bacteria.
Materials and methods. The research objects were 4 species of opportunistic Gram-negative bacteria. The test of sensitivity to antibiotics (17 drugs) and rose oil (2 samples) was studied by the disk-diffusion method.
Results. The comparative estimation showed the bactericidal and bacteriostatic effect of rose essential oils and antibiotics of various origin on the tested hospital strains. The synergetic and antagonistic effects were determined in vitro for combined influence of rose oil and antibiotics, perspective and recommended for each studied species.
Conclusions. The antibacterial effect of essential oils of roses on Stenotrophomonas maltophilia, Psеudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae was revealed. In several cases of antibiotic resistance of the tested cultures the intensity of bactericidal and bacteriostatic effects of essential oil exceeds
the ones of antibiotics with concentrations of 5…30 μg.

rose essential oil, antibiotics, combined action, opportunistic Gramnegative microorganisms, antibacterial effects.

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